I use iGoogle as my home page. I chose that one because I use gmail for my email.
On the first page I have links to my gmail, bloglines, weather, date and time, Google calendar, Quotes of the Day, my Google bookmarks, and Mapquest driving directions.
I also have a news page with news from a variety of sources. I have a humor page with some jokes and games. I have an entertainment page with gossip, movie times, and tv listings. And I have a sports page that follows my favorite teams.
It was easy to set up when I did it as a part of the first 23 things. I don't remember how to do it but I bet there are directions. I can't think of another page that I want to add.
I really like my Bloglines widget. It is good to see if I have any new blog messages whenever I open my home page.